Critical analysis of molecular tests in indeterminate thyroid nodules
نویسندگان
چکیده
منابع مشابه
Local molecular analysis of indeterminate thyroid nodules
BACKGROUND Thyroid nodules are common but only a minority are malignant. Molecular testing can assist in helping determine whether indeterminate nodules are suspicious for malignancy or benign. The objective of the study was to determine if the analysis of mutations (BRAF, NRAS, KRAS and HRAS) using readily available molecular techniques can help better classify indeterminate thyroid nodules. ...
متن کاملThyroid Nodules with Indeterminate Cytology
To the Editor: Alexander et al. (Aug. 23 issue)1 report findings from a prospective, multicenter gene-expression classifier validation study that raises several questions. For the 265 indeterminate fine-needle aspirates they tested, the geneexpression classifier had a sensitivity of 92%, a specificity of 52%, a positive predictive value of 47%, and a negative predictive value of 93%. Why the ob...
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Objectives To determine the diagnostic value of HRAS, KRAS, and NRAS mutations in fine-needle aspiration biopsies of thyroid nodules that are nondiagnostic on cytology. Data Sources PubMed, Scopus, Embase, CINAHL. Review Methods Two authors independently searched the data sources. To be included, studies reported the RAS mutational status and postoperative histopathologic diagnosis of nodules t...
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BACKGROUND Approximately 15 to 30% of thyroid nodules evaluated by means of fine-needle aspiration are not clearly benign or malignant. Patients with cytologically indeterminate nodules are often referred for diagnostic surgery, though most of these nodules prove to be benign. A novel diagnostic test that measures the expression of 167 genes has shown promise in improving preoperative risk asse...
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چکیده گفتگوگری باختین نظریه ای است که به تفاوت ها احترام گذاشته و گفتگو را ارج می نهد. رشته های مختلف علوم انسانی همواره از این نظریه بهره جسته اند. با وجود این تنها مطالعات اندکی در زمینه تجزیه و تحلیل نقادانه کلام به نظریه گفتگوگری پرداخته اند. پنداشت تحقیق حاضر بر آن است که احترام به حقوق دیگران از طریق فراهم آوردن شرایط یکسان برای بیان نظریات مختلف یکی از مهمترین مشترکات تحلیل انتقادی گفتم...
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ژورنال
عنوان ژورنال: Archives of Endocrinology and Metabolism
سال: 2018
ISSN: 2359-3997,2359-4292
DOI: 10.20945/2359-3997000000095